|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
[18F]‑FMISO uptake was significantly higher in HIF‑1α‑overexpressing xenograft tumors compared with control tumors.
|
29393454 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Xenograft experiments were conducted to compare the tumor growth ability and responsiveness to radioactive treatment among HIF-1α and β-catenin overexpressing FTC cells, respectively with or without β-catenin knockdown.
|
27840971 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Xenograft experiments in nude mice further showed that HIF-1α-shRNA inhibited tumor growth and caused persistent repression of HIF-1α and its target genes, including VEGF, GLUT1 and MMP2, up to 25 days post-inoculation.
|
24228093 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Wild-type IDH2 promotes the Warburg effect and tumor growth through HIF1α in lung cancer.
|
30128035 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
While HIF1α can act as a ccRCC tumor suppressor, HIF2α has emerged as the key HIF isoform that is essential for ccRCC tumor progression.
|
29938199 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
When tumor cells are exposed to hypoxia, hypoxia-inducible factor-1alpha (HIF-1alpha) is stabilized and activated to promote the transcription of several genes such as vascular endothelial growth factor (VEGF), but in the presence of E1A hypoxia-induced VEGF m-RNA synthesis is inhibited by E1A binding to p300.
|
16179928 |
2006 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Western blot analysis demonstrated that knockdown of talin2 in MDA-MB-231 cells caused marked downregulation of the tumor microenvironment markers hypoxia-inducible factor 1α, phosphorylated ribosomal protein S6 kinase, phosphorylated protein kinase B and phosphorylated mechanistic target of rapamycin.
|
31186690 |
2019 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We used human glioma tissues and derived brain tumor stem cells (BTSCs) to study the expression of HIF1α target genes in IDH mutant ((mt)) and IDH wild-type ((wt)) tumors.
|
24366912 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We therefore have outlined fluorescence-bioluminescence genetically encoded biosensor activated by the neoangiogenesis-related transcription factor HIF-1alpha, which is upregulated in growing tumors.
|
19423327 |
2009 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We suggest that HIF-1-alpha is a marker of malignancy in chondrosarcomas that correlates with tumor neo-angiogenesis.
|
30605014 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We presented a promising method for relieving the hypoxia degree in solid tumors and down-regulating HIF-1α protein by directly delivering oxygen into tumors, which will be very helpful for subsequent cancer therapy.
|
28985606 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We observed no significance between HIF-1α and CA IX expression in tumors with invasion, differentiation and in IIRC tumor groups.
|
23804414 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We investigated whether digoxin could suppress tumor cell growth through HIF-1α in non-small cell lung cancer cells (A549 cells) under hypoxic conditions.
|
23549264 |
2013 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We investigated the combined effects of Kanglaite (KLT) and cisplatin on tumor associated macrophage (TAM) and expression of hypoxia inducible factor-1 alpha (HIF-1α) in Kunming mice with Lewis lung carcinoma.
|
30087869 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We identify a dominant role for hypoxia, marked by HIF1α protein, in the tumor microvenvironment for shaping the regulome in a subset of epithelial tumor cells.
|
30389926 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We hypothesized that inhibiting HIF-1 and HIF-2 would further improve tumor response to sunitinib therapy.
|
19435875 |
2009 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We hypothesized that hypoxia-induced HIF-1alpha overexpression may also lead to tumor cells resistant to PDT by favouring tumor cell proliferation.
|
16427735 |
2006 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We hypothesized that fast growing tumor cells tend to predispose themselves to sublethal hypoxia and activate the HIF-1α signaling pathway, leading to hemorrhagic transformation in pituitary adenomas.
|
21822544 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We have reported critical roles for HIF-1α in tumor microenvironments, and oncogenic properties of HIF-1α have been suggested in malignancies.
|
27616748 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We have recently shown that induction of the p53 tumour suppressor protein by the small-molecule RITA (reactivation of p53 and induction of tumour cell apoptosis; 2,5-bis(5-hydroxymethyl-2-thienyl)furan) inhibits hypoxia-inducible factor-1α and vascular endothelial growth factor expression in vivo and induces p53-dependent tumour cell apoptosis in normoxia and hypoxia.
|
21593792 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We have recently demonstrated that cancer-associated fibroblasts (CAFs) elicit a redox-dependent epithelial-mesenchymal transition (EMT) in prostate cancer (PCa) cells, driven by cycloxygenase-2/hypoxia-inducible factor-1 (HIF-1)/nuclear factor-κB pathway and enhancing tumor aggressiveness.
|
23924028 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We found that TFAP2A was highly expressed in various nasopharyngeal carcinoma cell lines and tumor tissue specimens and was significantly correlated with hypoxia-inducible factor-1α (HIF-1α) expression.
|
24335623 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We found that following dual therapy, HIF-1alpha increases the activity of the canstatin-induced alpha(v)beta(5) signaling tumor apoptotic pathway and concomitantly abrogates mitotic checkpoint and tetraploidy triggered by radiation.
|
17557121 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We found that deletion of HIF-1α in NK cells inhibited tumour growth despite impaired tumour cell killing.
|
29150606 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We found that HIF-1α and LOX are highly expressed in epithelial ovarian cancer tissues, and the expression of both proteins is significantly correlated with the tumor grade, tumor diameter and lymph node metastasis.
|
23545606 |
2013 |